Perspectives On The News, March, 2008: Diabetic Neuropathy

POST-TEST QUESTIONS

1. Potential mechanisms of benefit of hyperbaric oxygen therapy include all the following EXCEPT:
  1. Increasing local oxygen delivery to hypoxic tissues
  2. Increasing tissue oxygenation by local vasodilatation
  3. causing local growth factor production

 

2. Hyperbaric oxygen therapy is NOT approved for reimbursement and NOT indicated for:

  1. osteomyelitis of the foot failing to respond to antibiotics and appropriate debridement
  2. foot wounds with evidence of gangrene failing to heal with 30 days of treatment
  3. foot wounds failing to heal with or without treatment after 90 days

 

3. Important forms of diabetic autonomic neuropathy include:

  1. Diabetic gastrointestinal autonomic neuropathy
  2. Diabetic cardiovascular autonomic neuropathy
  3. Diabetic peripheral autonomic neuropathy
  4. All of the above

 

4. The NH2-terminal fragment of the brain natriuretic peptide may be increased in diabetic patients with

  1. Cardiovascular disease
  2. Increasing age
  3. Diabetic peripheral neuropathy
  4. All of the above
  5. (a) and (b) only

 

5. Diabetic peripheral neuropathy may be a function of hyperglycemia and a variety of additional factors. In data from the DCCT, prevalence of neuropathy was shown to be greater in:

  1. Taller rather than shorter persons with intensive glycemic treatment.
  2. Taller rather than shorter persons with conventional glycemic treatment.
  3. Taller rather than shorter persons regardless of the level of treatment.



6: Some evidence suggests that diabetic neuropathy may improve following treatment with:

  1. statins
  2. fibrates
  3. alpha lipoic acid
  4. all of the above
  5. (a) and (b) only

 

7. True or False: Potential adverse effects of diabetic cardiovascular autonomic neuropathy include congestive heart failure, arrhythmias or orthostatic hypotension.

  1. True
  2. False

 


8. True or False: Vitamin D deficiency may play a role in the development of Charcot arthropathy in persons with diabetes.

  1. True
  2. False

 

9. In the United States, what proportion of persons with gastroparesis are diabetic and how likely is it that diabetic persons will be symptomatic?

  1. One half are diabetic patients with 20 – 50% symptomatic
  2. One third are diabetic patients with 60 – 70% symptomatic
  3. One third are diabetic patients with 10 – 25% symptomatic
  4. One quarter are diabetic patients with one quarter symptomatic