a.  increased heptic uptake of circulating fatty acids
b.  increased hepatic de novo synthesis of fatty acids
c.  relative depletion of polyunsaturated fatty acids
d.  increased inrahepatic free cholesterol without change in esterifed cholesterol
e.  increased lipid peroxidation with mitochondrial dysfunction
f.   all of the above

 

2. The 5-year likelihood of progression of NASH is:

a.   2 - 4%
b.   5 - 10%
c.  15 - 25%
d.  30 - 45%
e.   > 50%

 

3. Abnormal hepatic transaminase levels in persons with diabetes:

a.  typically indicate the presence of NASH
b.  rule out simple hepatic steatosis
c.  are associated with NASH about as often as they are with other forms of liver disease

4. Potential approaches for treatment of NASH include:

a. measures to promote weight loss
b. administration of inhibitors of the renin-angiotensin system
c. administration of insulin sensitizers
d. all of the above

5. In extending the concept of the insulin resistance syndrome (IRS) to childhood, this complex of factors can be identified in:

a.  2-10% of 5-11 year-old children
b.  12-15% of 5-11 year-old children
c.  18-25% of 5-11 year-old children

 

6. Which of the following is associated with an increased risk of insulin resistance in childhood?

a. maternal obesity
b. low-for-gestational age neonatal weight
c. breast feeding
d. all of the above
e. ‘a’ and ‘b’ only

 

7. The nadir of insulin sensitivity in childhood is seen:

a.  at the oldest age
b.  at the end of puberty
c.  at the beginning of puberty

 

8. Childhood IRS is a function of:

a. increased BMI
b. decreased insulin sensitivity
c. both obesity and reduced insulin sensitivity